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Extramedullary myeloid sarcoma mimicking tuberculosis of spine: A case report and literature review
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How to cite this article: Patgaonkar P, Goyal V, Marathe N. Extramedullary myeloid sarcoma mimicking tuberculosis of spine: A case report and literature review. Surg Neurol Int 2021;12:178.
Abstract
Background:
A definitive diagnosis of spinal tuberculosis (TB) remains challenging. The “gold standard” is to obtain histopathological confirmation of the lesion. This analysis highlights how to avoid missing the diagnosis of an extramedullary myeloid sarcoma (EMS) versus TB.
Case Description:
A 25-year-old male presented with paraparesis. Although this was first attributed to TB spondylodiscitis, a PET-CT and reevaluation of the biopsy specimen both confirmed the diagnosis of an EMS.
Conclusion:
Nontubercular spinal disease should be suspected when a patient deteriorates despite the institution of antitubercular therapy for a reasonable duration. Further, microbiological and/or pathological confirmation is warranted to direct appropriate treatment and differentiate spinal TB from other entities as, in this case, an EMS.
Keywords
Myeloid sarcoma
Spine
Tuberculosis
INTRODUCTION
Extramedullary myeloid sarcoma (EMS) may involve any organ or tissue. Skin, bone, and lymph nodes are most frequently affected, with vertebral involvement being extremely rare. Here, we present a 25-year-old male who was originally diagnosed and treated for tuberculosis (TB) of spine, where the ultimate correct diagnosis was EMS.
CASE REPORT
A 25-year-old male originally presented with mid-back pain of 2 months duration. After a T8 thoracic CT-guided biopsy, he was diagnosed/treated for TB spondylitis with bed rest and appropriate antibiotic therapy. However, 1 month following his initial presentation, he developed worsening of his mid-back pain (VAS score 8), chest pain, shortness of breath, and a progressive lower extremity paraparesis (3/5 proximal and 4/5 distal).
X-ray and MR studies
The chest X-ray showed a pleural effusion, while the thoracic spine X-ray demonstrated T8 vertebral collapse. Further, the thoracic spine MRI showed a posterior epidural collection extending from T7 to T9 resulting in cord compression. Of interest, lumbar X-rays and lumbar MR scan both demonstrated an additional although smaller, asymptomatic L3 vertebral body lesion [Figures 1 and 2].
Surgery
The patient’s progressive myelopathy prompted a T8, T9 laminectomy that included a culture/biopsy of the lesion, epidural debridement, and T6-T10 pedicle screw fixation [Figure 3]. Notably, at the T8 level, there was a nonpurulent, soft, grayish-white material found in the center of the T8 vertebral body that appeared more consistent with tumor than tubercular infection.
Pathology/culture
The pathology showed only inflammatory granulation tissue, and the staining for all organisms, including Mycobacterium tuberculosis (MTB), was negative [Figure 4].
Postoperative course
Postoperatively, the patient’s back pain (VAS score 2) improved, and he showed significant neurological recovery (e.g., 4/5 function proximally, 5/5 distally). However, within 3 days, he developed an increased left-sided pleural effusion (1700 cc). Tissue culture and MTB DNA reverse transcriptase-polymerase chain reaction of the fluid were negative. Four weeks postoperatively, when he returned with dyspnea and cough, the PET-CT scan revealed a metabolically active osteolytic lesion predominantly involving the T8 vertebral body, with extension into the T7, T9, and T11 vertebral bodies, involving the left 7th rib, as well as multiple other sites [Figure 5a].
Biopsy of the left 7th rib and immunohistochemistry studies confirmed that the lesion was an EMS [Figure 5b]. At that point, the patient was referred for chemotherapy (e.g., cytarabine + daunorubicin). Now 1 year following the completion of chemotherapy, he remains asymptomatic, and the EMS has not yet recurred.
DISCUSSION
Frequency and differential diagnosis for EMS
EMS (also known as myeloid sarcoma MS, granulocytic sarcoma, or myeloblastoma) is rare. Patients ages can range from 1 to 81. EMS commonly affects skin, bone, and lymph nodes, but rarely presents in the spine.[2,3] Misdiagnosis is often seen in EMS with differential diagnoses including lymphoma, undifferentiated malignancies, extramedullary hematopoiesis, and inflammatory pathologies (i.e., TB that is more common and endemic in India) [Table 1].[4,6,8]
Diagnostic studies for EMS
EMS can present as single or multifocal lesions; 2–8% of these patients will have acute myeloid leukemia (AML). CT and MRI studies help differentiate EMS from hemorrhage or abscesses. Stölzel et al. emphasized that fluorodeoxyglucose PET-CT also additionally helped document extramedullary AML.[7] There are also multiple treatment regimens for MS with or without AML, including conventional AML chemotherapy.[1,5]
CONCLUSION
EMSs of the spine are rare. They must be biopsy confirmed to differentiate them from TB spondylodiscitis (i.e., in endemic areas) and other lesions.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
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