Translate this page into:
Notice: Please configure GTranslate from WP-Admin -> Settings -> GTranslate to see it in action.
Brainstem intraparenchymal schwannoma: A case report and literature review
-
Received: ,
Accepted: ,
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Kovalainen A, Haeren R, Paetau A, Lehecka M. Brainstem intraparenchymal schwannoma: A case report and literature review. Surg Neurol Int 2021;12:508.
Abstract
Background:
Intracranial intraparenchymal schwannomas (IS) are rare tumors that have mainly been described in case reports. Here, we report on a case of a brainstem IS and included a comprehensive literature review.
Case Description:
A 74-year-old man presented with progressive gait disturbances. CT- and MRI-imaging revealed a contrast-enhancing mass accompanied by a cyst in the dorsolateral pons. Hemangioblastoma was suspected and surgery was advised. During surgery, gross total resection of a non-invasive tumor was performed. Postoperative recovery was uneventful. Based on histopathological examination, the intraparenchymal brainstem tumor was diagnosed as schwannoma.
Conclusion:
Our extensive review illustrates that ISs are benign tumors that most often present in relatively young patients. Malignant cases have been described but form an extremely rare entity. Preoperative diagnosis based on radiological features is difficult but should be considered when peritumoral edema, calcifications, and cysts are noted. In benign cases, gross total resection of the lesion is curative. To adequately select this treatment and adjust the surgical strategy accordingly, it is important to include IS in the preoperative differential diagnosis when the abovementioned radiological features are present.
Keywords
Brainstem
Case report
Intraparenchymal
Review
Schwannoma
Tumor
INTRODUCTION
Schwannomas are tumors that originate from Schwann cells, which form the myelin sheath of peripheral nerves.[15] Intracranial schwannomas comprise around 8% of all primary brain tumors, with the vast majority arising from the cranial nerves.[2,7] Less than 1% of intracranial schwannomas are located within the brain parenchyma.[1,11] The first case of intraparenchymal schwannoma (IS) was described by Gibson et al. in 1966.[5] Their histogenesis remains speculative, and radiological and histopathological diagnosis can be extremely difficult. Here, we present a case of a brainstem IS and included a comprehensive review on IS to shed light on the clinical, radiological, and histopathological characteristics.
CASE REPORT
A 74-year-old man with no reported prior medical condition presented with progressive gait disturbances and hearing loss that had developed over a few months. Neurological examination revealed sensory asymmetry in the left upper and middle trigeminal branch areas, broad-based gait, diplopia, dysphagia, and dysarthric speech. Imaging studies showed a cystic tumor in the left dorsolateral pons [Figure 1]. A pontine hemangioblastoma was suspected and surgery was recommended.
A left-sided suboccipital retrosigmoid craniotomy was performed [Video 1]. Intra-operative monitoring of trigeminal, facial, and vestibulocochlear nerve was used. An opaque aspect of the dorsolateral pons was noted and punctured, relieving a yellowish fluid. The solid mass consisted of flakey grey-yellowish tissue that was not invasive into the surrounding brain. Intraoperatively, the tumor resembled a pilocytic astrocytoma more than a hemangioblastoma. Gross total resection was performed. Postoperatively, all symptoms had alleviated and hearing had subjectively returned to normal. The direct postoperative MRI showed a small dorsomedial remnant. Radiological follow-up after 1 year was agreed upon.
Video 1:Video 1:
Video 1:: The most relevant intraoperative findings of the resection of an intraparenchymal schwannoma located in the dorsolateral pons displayed in a surgical video.Histological assessment of the tumor sections showed clusters of spindle cells surrounded by fascicles and palisades in addition to thick-walled vessels [Figure 2a]. Some paucicellular areas were present, but no typical cystic spaces. Additional immunohistochemical examination exhibited positivity for S-100 protein, pericellular collagen IV basement membrane staining, and in some areas scattered few neurofilament (NF2F11) positive intratumoral axons [Figure 2b-d]. GFAP glial marker was negative, and MIB-1 proliferative activity was only 2%. The final histopathological diagnosis was IS Grade I. No clinical signs nor family history of neurofibromatosis (NF) was reported.
DISCUSSION
IS s are rare intracranial intra-axial tumors. We have found 150 cases reporting on histopathological confirmed IS [Table 1]. Intraventricular or schwannomas with dural attachment were excluded from our review as they form a different entity with an extra-axial origin. Based on our literature review, we will discuss characteristics of the clinical presentation, histogenesis, radiological features, histopathological findings, treatment, and prognosis of IS.
Clinical characteristics
ISs present at a relatively young age, with a majority occurring before the age of 30 and a slight male predominance [Table 2]. Around 65% of these tumors were located supratentorially and 35% infratentorially. The frontal lobe was most frequently affected [Table 3]. Only six cases of patients older than 70 years have been reported. Furthermore, we found only nine cases with pontine IS. This makes our case on a 74-year-old with a pontine IS unique.
Clinical presentation and clinical course are mostly dependent on tumor location and increased intracranial pressure. Tumors involving functional areas may be associated with a relatively short time between presentation and diagnosis.[4] According to our review, the occurrence of IS in a patient with NF was reported in 10% of the cases.
Histogenesis
Schwannomas originate from Schwann cells, which form the myelin sheath of peripheral nerves.[15] Since Schwann cells are usually not present within the brain parenchyma, the origin of IS has attracted much speculation.[8,13,22] Various theories have been proposed to explain the origin of IS. Menkü et al. differentiated these theories into developmental and non-developmental theories.[13] According to the developmental theory, a distorted embryogenesis forms the source of aberrant foci of Schwann cells in the brain parenchyma. These foci may originate from transformation of developed mesenchymal pial cells into Schwann cells, differentiation of multipotential mesenchymal elements into Schwann cells, ectopic migration of neural crest cells forming foci of Schwann cells, or misplaced myelinated nerve fibers.[11,13,15] The non-developmental theory suggests that the intraparenchymal Schwann cells originate from the perivascular nerve plexus of parenchymal arterioles.[11,13,15] The relative rarity of ISs is in this latter theory explained by considering the relative amounts of peripheral as opposed to parenchymal myelinated peripheral nerve plexus.
In our case, one could suggest a relation of the tumor with Schwann cells of the trigeminal nerve. However, the radiological findings suggested an intraparenchymal origin of the tumor as there was no border between the brainstem and the tumor. In addition, the tumor was located within the brainstem parenchyma as observed intraoperatively. If the tumor was related to trigeminal nerve Schwann cells, one would have expected a capsule between the Schwannoma and the brainstem which was not apparent in this case. Since the intraparenchymal myelin covering of the trigeminal nerve is dependent on astrocytes, and not Schwann cells, it is unlikely that the tumor is directly related to the trigeminal nerve.[16]
Radiological features
Diagnosis of IS based on preoperative radiological examinations is difficult. Our review revealed that a wide variety of differential diagnoses were suspected preoperatively and IS was not considered in any of these cases [Table 1]. CT-images of the brain may show a hypodense and sometimes hyperdense mass with occasional cysts, calcifications, and peritumoral edema.[7,14] The mass lesion and cyst wall may enhance following contrast administration. ISs usually appear hypointense and hyperintense on T1-weighted and T2-weighted MRI sequences, respectively.[11,14,20] The solid portion and cyst wall usually show homogeneous enhancement with gadolinium.[14] It is noteworthy that peritumoral edema, cyst formation and calcifications are commonly reported characteristics of IS, yet they lack specificity.[14,20,22]
In contrast, cranial nerve Schwannomas are radiologically characterized by a heterogeneous hyperintensity in T2-weighted images, with deformation of adjacent parenchyma, neural cisterns and bony foramina, and have a clear relation to a cranial nerve. Moreover, cranial nerve Schwannomas usually have a well delineated margin from the brainstem parenchyma and cause minimal peritumoral edema.[19]
Histopathological findings
Histological evaluation of IS shows a typical biphasic tissue pattern of Antoni type A and B areas.[12] It remains however difficult to differentiate IS from other tumors without immunohistochemical examination.[7] As there are no schwannoma-specific immunohistochemical markers to date, several markers should be included to differentiate schwannomas from other tumors. Schwannomas show a strong diffuse reactivity to S-100 protein and vimentin filament.[7] There is usually no reactivity for GFAP, EMA, CD34 on endothelial cells or α-SMA, excluding glial tumors, meningiomas, solitary fibrous tumors, and smooth muscle cell tumors, respectively.[1,7,12] The combination of histological analysis and immunohistochemical reactivity findings is required to make a definite diagnosis of IS. Malignant IS, often called malignant intracerebral nerve sheath tumor (MINST), is extremely rare. Compared to benign IS, MINST are characterized by a high mitotic activity and Ki-labeling index.[9,18] A variant of MINST is a triton tumor, which is characterized additionally by rhabdomyoblastic components.[3]
Treatment and prognosis
Since IS are mostly benign lesions, gross total or complete resection of the tumor is usually curative. Therefore, surgical resection is the preferred treatment for symptomatic lesions.[7] We calculated a recurrence rate of 5.3% following gross total or complete resection [Table 1]. All recurrences were related to malignant histopathology. In cases with subtotal resection, only four patients required reoperation because of residual tumor or recurrence.[4,6,21,22] None of these recurrent cases were related to malignant pathology, suggesting that recurrence was the result of subtotal resection. Mortality rate among histopathological benign IS cases was 0% compared to 53% in malignant cases [Table 1].
Although rare, IS should be included in the differential diagnosis when typical radiological features are present. This is relevant as surgical approach and technique may be different in comparison to the many differential diagnoses that are included in [Table 1]. For example, IS can be removed in a piecemeal intratumoral debulking fashion, whereas hemangioblastomas, being the preoperative suspected diagnosis in our case, requires an en bloc removal and entering the tumor could result in unnecessary blood loss. Similarly, in some cases, high grade glioma (of the brainstem) was the preoperative suspected diagnosis [Table 1] which may result in diagnostic biopsy surgery instead of surgical resection. Therefore, including IS in the differential diagnosis when typical radiological features are present is relevant for the surgical strategy.
The role of radiotherapy or chemotherapy as primary treatment of benign IS remains unknown. We found two cases in which radiotherapy was given as primary treatment.[10,17] In both cases, radiotherapy failed to reduce tumor size and tumor-related symptoms after which surgery was performed. Radiotherapy and chemotherapy may play a role as adjuvant treatment in malignant IS cases.[18]
CONCLUSION
ISs are rare benign tumors occurring mostly in young patients. Clinical presentation is usually related to tumor location or increased intracranial pressure. Gross total resection of the lesion is curative. To adjust the surgical strategy accordingly, ISs should be considered preoperatively when radiological features such as peritumoral edema, calcifications, and cysts are noted.
Acknowledgments
None.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
Video available on:
REFERENCES
- Intracranial parenchymal schwannoma. J Neurosurg. 2009;79:217-22.
- [Google Scholar]
- Intraparenchymal schwannoma with calcification of the temporal lobe: Case report and literature review. Medicine (Baltimore). 2019;98:e14263.
- [Google Scholar]
- An intracerebral intraparenchymatous triton tumor in a man with neurofibromatosis. J Neurol. 2007;254:1009-11.
- [Google Scholar]
- Intracerebral schwannoma: Case report and review. Neurosurg Rev. 1996;19:269-74.
- [Google Scholar]
- Intracerebral schwannoma. Report of a case. J Neurosurg. 1966;24:552-7.
- [Google Scholar]
- Supratentorial intracerebral schwannomas. Surg Neurol. 1984;22:69-72.
- [Google Scholar]
- Periventricular intraparenchymal schwannoma. Case report. Neurol Med Chir (Tokyo). 2012;52:603-7.
- [Google Scholar]
- Frontal intraparenchymal schwannoma. J Clin Neurosci. 2011;18:411-3.
- [Google Scholar]
- Intrapontine malignant nerve sheath tumor: MRI and MRS features. Acta Neurol Belg. 2008;108:67-71.
- [Google Scholar]
- Intraparenchymal schwannoma of the medulla oblongata: Case report. J Neurosurg. 2003;98:621-4.
- [Google Scholar]
- Intracranial intraparenchymal and intraventricular schwannomas: Report of 18 cases. Clin Neurol Neurosurg. 2013;115:1052-7.
- [Google Scholar]
- Supratentorial intraparenchymal schwannoma mimicking a glial tumor. Neurol India. 2012;60:335-7.
- [Google Scholar]
- Atypical intracerebral schwannoma mimicking glial tumor: Case report. Turk Neurosurg. 2009;19:82-5.
- [Google Scholar]
- Imaging and clinical features of an intra-axial brain stem schwannoma. Am J Neuroradiol. 2010;31:567-9.
- [Google Scholar]
- Intraparenchymal schwannomas: Report of two new cases studied with MRI and review of the literature. Clin Neurol Neurosurg. 2012;114:42-6.
- [Google Scholar]
- Microanatomy of the central myelin-peripheral myelin transition zone of the trigeminal nerve. Neurosurgery. 2006;59:354-9.
- [Google Scholar]
- Schwannoma of the medulla oblongata. Br J Neurosurg. 1993;7:427-9.
- [Google Scholar]
- Malignant intracerebral nerve sheath tumors: A case report with review of the literature. Case Rep Surg. 2013;2013:384076.
- [Google Scholar]
- Cranial nerve schwannomas: Diagnostic imaging approach. Radiographics. 2016;36:1463-77.
- [Google Scholar]
- Intracranial intraparenchymal schwannoma: Report of three cases. Acta Neurochir (Wien). 1997;139:756-60.
- [Google Scholar]
- Primary intrasellar schwannoma: Case report. Surg Neurol. 1989;32:156-8.
- [Google Scholar]
- Intra-and extramedullary dumbbell-shaped schwannoma of the medulla oblongata: A case report and review of the literature. World Neurosurg. 2017;98:873.e1-7.
- [Google Scholar]
